DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

The integrity of our genetic material is under constant attack from numerous endogenous
and exogenous agents. The consequences of a defective DNA damage response are well …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human …

Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of
defense have evolved to reduce the accumulation of DNA damage, including reducing …

The ability to respond to genotoxic stress is a prerequisite for the successful development of
the nervous system. Mutations in various DNA repair factors can lead to human diseases …

The human brain forms functional networks of correlated activity, which have been linked
with both cognitive and clinical outcomes. However, the genetic variants affecting brain …

Active maintenance of genome stability is a prerequisite for the development and function of
the nervous system. The high replication index during neurogenesis and the long life of …

Xeroderma pigmentosum (XP) is a rare disorder of defective UV-radiation induced damage
repair that is characterized by photosensitivity with easy skin burning following minimal sun …