[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
Microglia in the retina: roles in development, maturity, and disease
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
TMT labeling for the masses: a robust and cost-efficient, in-solution labeling approach*[S]
Isobaric stable isotope labeling using, for example, tandem mass tags (TMTs) is increasingly
being applied for large-scale proteomic studies. Experiments focusing on proteoform …
being applied for large-scale proteomic studies. Experiments focusing on proteoform …
[HTML][HTML] Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
Retinal degeneration and Alzheimer's disease: an evolving link
Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …
Neuroprotective strategies for retinal ganglion cell degeneration: current status and challenges ahead
R Boia, N Ruzafa, ID Aires, X Pereiro… - International journal of …, 2020 - mdpi.com
The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …
Discovery and clinical translation of novel glaucoma biomarkers
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …
Targeting microglia to treat degenerative eye diseases
Microglia have been implicated in many degenerative eye disorders, including retinitis
pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and …
pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and …
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative …
Single cell RNA sequencing studies identified novel neurodegeneration-associated
microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA …
microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA …