Leveraging NKG2D ligands in immuno-oncology
Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …
new avenues towards the development of novel assets to achieve durable immune control …
The emerging role of ADAM metalloproteinases in immunity
BN Lambrecht, M Vanderkerken… - Nature Reviews …, 2018 - nature.com
Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …
activation of protein function. Many transmembrane proteins that are involved in the cellular …
[HTML][HTML] Role of NKG2D and its ligands in cancer immunotherapy
H Liu, S Wang, J **n, J Wang, C Yao… - American journal of …, 2019 - ncbi.nlm.nih.gov
The activating receptor natural killer group 2, member D (NKG2D) is involved in both innate
and adaptive immunities, and functions as a “master switch” in determining the activation …
and adaptive immunities, and functions as a “master switch” in determining the activation …
NKG2D ligands–critical targets for cancer immune escape and therapy
D Schmiedel, O Mandelboim - Frontiers in immunology, 2018 - frontiersin.org
DNA damage, oncogene activation and excessive proliferation, chromatin modulations or
oxidative stress are all important hallmarks of cancer. Interestingly, all of these abnormalities …
oxidative stress are all important hallmarks of cancer. Interestingly, all of these abnormalities …
Targeting ADAM10 in cancer and autoimmunity
Generating inhibitors for AD isintegrin A nd M etalloproteinase 10 (ADAM10), a zinc-
dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 …
dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 …
[HTML][HTML] The metalloproteinase ADAM10: A useful therapeutic target?
S Wetzel, L Seipold, P Saftig - … et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
Proteolytic cleavage represents a unique and irreversible posttranslational event regulating
the function and half-life of many intracellular and extracellular proteins. The …
the function and half-life of many intracellular and extracellular proteins. The …
New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)
D Rosenbaum, P Saftig - The FEBS journal, 2024 - Wiley Online Library
The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …
NK cells to cure cancer
Natural Killer (NK) cells are innate lymphocytes able to mediate immune-surveillance and
clearance of viral infected and tumor-transformed cells. Growing experimental and clinical …
clearance of viral infected and tumor-transformed cells. Growing experimental and clinical …
The importance of the PD-1/PD-L1 pathway at the maternal-fetal interface
Background Our goal with this study was to investigate the contribution of PD-1/PD-L1
immune-checkpoint pathway to maternal immunotolerance mechanisms. Methods Thirteen …
immune-checkpoint pathway to maternal immunotolerance mechanisms. Methods Thirteen …
How to hit mesenchymal stromal cells and make the tumor microenvironment immunostimulant rather than immunosuppressive
Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate
tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence …
tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence …