Poor therapeutic outcomes of antioxidants in ophthalmologic clinical applications, including
glutathione during photoreceptor degeneration in retinitis pigmentosa (RP), are caused by …

Rhodopsin is a light-sensitive G protein-coupled receptor that initiates the phototransduction
cascade in rod photoreceptors. Mutations in the rhodopsin-encoding gene RHO are the …

Congenital stationary night blindness (CSNB) is an inherited retinal disease that causes a
profound loss of rod sensitivity without severe retinal degeneration. One well-studied …

Retinal rods and cones underlie scotopic and photopic vision, respectively. Their pigments
exhibit spontaneous isomerizations (quantal noise) in darkness due to intrinsic thermal …

Mutations in rhodopsin can cause it to misfold and lead to retinal degeneration. A
distinguishing feature of these mutants in vitro is that they mislocalize and aggregate. It is …

Retinitis pigmentosa (RP) is caused by one of many possible gene mutations. The National
Institutes of Health recommends high daily doses of vitamin A palmitate for RP patients …

Almost a century ago, Stiles and Crawford reported that the human eye is more sensitive to
light entering through the pupil center than through its periphery (Stiles-Crawford effect) …

Retinal rod and cone photoreceptors mediate vision in dim and bright light, respectively, by
transducing absorbed photons into neural electrical signals. Their phototransduction …

Vertebrate eyes share the same general organization, though species have evolved
morphological and functional adaptations to diverse environments. Cave-adapted animals …