Although it is broadly agreed that the improved treatment of patients with cancer will depend
on a deeper molecular understanding of the underlying pathogenesis, only a few examples …

Schizophrenia is a highly debilitating mental disorder that affects∼ 1% of the general
population, yet it continues to be poorly understood. Recent studies have identified …

Human epidermal growth factor receptor-2 (HER2/erbB-2) belongs to a family of four
transmembrane receptors involved in signal transduction pathways that regulate cell growth …

Overexpression of ErbB2, a receptor-like tyrosine kinase, is shared by several types of
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …

Human epidermal growth factor receptors (HER/erbB) constitute a family of four cell surface
receptors involved in transmission of signals controlling normal cell growth and …

Publisher Summary Carcinoma, cancer of epithelial cells, is a major cause of morbidity and
mortality. Clonal fixation and propagation of oncogenic genetic changes, sporadically …

ErbB receptor activation is a complex process and is dependent upon the type and number
of receptors expressed on a given cell. Previous studies with defined combinations of ErbB …

The ErbB/HER family of receptor tyrosine kinases consists of four receptors that bind a large
number of growth factor ligands sharing an epidermal growth factor-(EGF)-like motif …

The mammalian target of rapamycin, commonly known as mTOR, is a serine/threonine
kinase that regulates translation and cell division. mTOR integrates input from multiple …

The epidermal growth factor receptor family consists of four receptor genes and at least 11
ligands, several of which are produced in different protein forms. They create an interacting …