Application of exosomes as liquid biopsy in clinical diagnosis

B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …

Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Tracking placental development in health and disease

JD Aplin, JE Myers, K Timms… - Nature Reviews …, 2020 - nature.com
Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Unlocking the power of exosomes for crossing biological barriers in drug delivery

RO Elliott, M He - Pharmaceutics, 2021 - mdpi.com
Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …

The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets

M Ghafourian, R Mahdavi, Z Akbari Jonoush… - Cell Communication and …, 2022 - Springer
Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles
originating from different cell compartments. EVs participate in many essential physiological …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Phenotypic analysis of extracellular vesicles: a review on the applications of fluorescence

MS Panagopoulou, AW Wark, DJS Birch… - Journal of extracellular …, 2020 - Taylor & Francis
Extracellular vesicles (EVs) have numerous potential applications in the field of healthcare
and diagnostics, and research into their biological functions is rapidly increasing. Mainly …

[HTML][HTML] Exosomes as messengers between mother and fetus in pregnancy

L Czernek, M Düchler - International Journal of Molecular Sciences, 2020 - mdpi.com
The ability of exosomes to transport different molecular cargoes and their ability to influence
various physiological factors is already well known. An exciting area of research explores …

Circulating extracellular vesicles in healthy and pathological pregnancies: A sco** review of methodology, rigour and results

MVC Barnes, P Pantazi, B Holder - Journal of Extracellular …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) play a crucial role in pregnancy, revealed by the presence of
placental‐derived EVs in maternal blood, their in vitro functionality, and their altered cargo in …

Placental function and the development of fetal overgrowth and fetal growth restriction

JH Dumolt, TL Powell… - Obstetrics and Gynecology …, 2021 - obgyn.theclinics.com
The develo** fetus undergoes a dynamic period of rapid growth that is responsive to
changes in the in utero environment that may contribute to the development of fetal growth …