Poly (ADP-ribosyl) ation by PARP-1:PAR-laying'NAD+ into a nuclear signal
Poly (ADP-ribose)(PAR) and the PAR polymerases (PARPs) that catalyze its synthesis from
donor nicotinamide adenine dinucleotide (NAD+) molecules have received considerable …
donor nicotinamide adenine dinucleotide (NAD+) molecules have received considerable …
Narrowing down the targets: towards successful genetic engineering of drought-tolerant crops
S Yang, B Vanderbeld, J Wan, Y Huang - Molecular plant, 2010 - cell.com
Drought is the most important environmental stress affecting agriculture worldwide.
Exploiting yield potential and maintaining yield stability of crops in water-limited …
Exploiting yield potential and maintaining yield stability of crops in water-limited …
Poly (ADP‐ribose) polymerase in plants affects energy homeostasis, cell death and stress tolerance
MD Block, C Verduyn, DD Brouwer… - The Plant …, 2005 - Wiley Online Library
Plants contain two genes that code for poly (ADP‐ribose) polymerase (PARP): parp1 and
parp2. Both PARPs are activated by DNA damage caused by, example reactive oxygen …
parp2. Both PARPs are activated by DNA damage caused by, example reactive oxygen …
The role of poly (ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes
Patients with diabetes exhibit a high incidence of diabetic cardiomyopathy and vascular
complications, which underlie the development of retinopathy, nephropathy, and neuropathy …
complications, which underlie the development of retinopathy, nephropathy, and neuropathy …
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease
Dysfunction of mitochondrial complex I is associated with a wide spectrum of
neurodegenerative disorders, including Parkinson's disease (PD). In rodents, inhibition of …
neurodegenerative disorders, including Parkinson's disease (PD). In rodents, inhibition of …
Poly (ADP-ribose) is required for spindle assembly and structure
P Chang, MK Jacobson, TJ Mitchison - Nature, 2004 - nature.com
The mitotic spindle is typically thought of as an array of microtubules, microtubule-
associated proteins and motors that self-organizes to align and segregate chromosomes …
associated proteins and motors that self-organizes to align and segregate chromosomes …
Activation of poly (ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus
Necrotic cells release inflammatory mediators that activate cytokine production from innate
immune cells. One mediator of this activation is high mobility group box 1 protein (HMGB1) …
immune cells. One mediator of this activation is high mobility group box 1 protein (HMGB1) …
Activation of poly (ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation
Recent studies demonstrated that activation of the nuclear enzyme poly (ADP-ribose)
polymerase-1 (PARP-1) by oxidant-mediated DNA damage is an important pathway of …
polymerase-1 (PARP-1) by oxidant-mediated DNA damage is an important pathway of …
Targeting parthanatos in ischemic stroke
Parthanatos is a cell death signaling pathway in which excessive oxidative damage to DNA
leads to over-activation of poly (ADP-ribose) polymerase (PARP). PARP then generates the …
leads to over-activation of poly (ADP-ribose) polymerase (PARP). PARP then generates the …
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating
Clathrin-coated pits invaginate from specific membrane compartments and pinch off as
coated vesicles. These vesicles then uncoat rapidly once released. The Hsc70 molecular …
coated vesicles. These vesicles then uncoat rapidly once released. The Hsc70 molecular …