Review of signaling pathways governing MSC osteogenic and adipogenic differentiation

AW James - Scientifica, 2013 - Wiley Online Library
Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

Natural history of mesenchymal stem cells, from vessel walls to culture vessels

IR Murray, CC West, WR Hardy, AW James… - Cellular and Molecular …, 2014 - Springer
Mesenchymal stem/stromal cells (MSCs) can regenerate tissues by direct differentiation or
indirectly by stimulating angiogenesis, limiting inflammation, and recruiting tissue-specific …

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

Y Rinkevich, GG Walmsley, MS Hu, ZN Maan… - Science, 2015 - science.org
INTRODUCTION Fibroblasts are the predominant cell type that synthesizes and remodels
the extracellular matrix in organs during both embryonic and adult life and are central to the …

Radiation-induced skin fibrosis: pathogenesis, current treatment options, and emerging therapeutics

MR Borrelli, AH Shen, GK Lee, A Momeni… - Annals of plastic …, 2019 - journals.lww.com
Radiotherapy (RT) has become an indispensable part of oncologic treatment protocols for a
range of malignancies. However, a serious adverse effect of RT is radiodermatitis; almost …

The role of endoglin and its soluble form in pathogenesis of preeclampsia

G Margioula-Siarkou, C Margioula-Siarkou… - Molecular and Cellular …, 2022 - Springer
Preeclampsia remains till today a leading cause of maternal and fetal morbidity and
mortality. Pathophysiology of the disease is not yet fully elucidated, though it is evident that it …

Endoglin: beyond the endothelium

MJA Schoonderwoerd, MJTH Goumans… - Biomolecules, 2020 - mdpi.com
Endoglin, a type-III accessory receptor for the Transforming Growth Factor (TGF)-β
superfamily pathway, is known for its crucial role during angiogenesis. Extensive work has …

Bone marrow aspirate concentrate quality is affected by age and harvest site

C Cavallo, A Boffa, L de Girolamo, G Merli… - Knee Surgery, Sports …, 2023 - Springer
Purpose To compare the number and properties of bone marrow stromal cells (BMSCs)
collected from bone marrow aspirate concentrate (BMAC) obtained from different harvest …

Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations

RC Rennert, M Sorkin, M Januszyk, D Duscher… - Stem cell research & …, 2014 - Springer
Introduction Pathophysiologic changes associated with diabetes impair new blood vessel
formation and wound healing. Mesenchymal stem cells derived from adipose tissue (ASCs) …

Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells

D Duscher, RC Rennert, M Januszyk, E Anghel… - Scientific reports, 2014 - nature.com
Advanced age is associated with an increased risk of vascular morbidity, attributable in part
to impairments in new blood vessel formation. Mesenchymal stem cells (MSCs) have …

TGF-β and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer

V de Araújo Farias, AB Carrillo-Gálvez, F Martin… - Cytokine & Growth …, 2018 - Elsevier
Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-based therapy in
regenerative medicine and for the treatment of inflammatory/autoimmune diseases …