MUC16 (the cancer antigen CA125) is the most commonly used serum biomarker in
epithelial ovarian cancer, with increasing levels reflecting disease progression. It is a …

Mucin 1 (MUC1) is a membrane-bound, highly glycosylated protein that is overexpressed in
all stages of malignant transformation. Overexpression of MUC1 together with loss of …

Glycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to
that which is presented by healthy cells. One of such changes is appearing tumor …

Simple Summary Tumor cells accumulate sialylation in tissues via the coordination of
sialyltransferases and sialidases. Tumor sialylation can block receptor and ligand binding at …

Gynecological cancers are in the top 10 of most common cancers in women. Survival and
outcome are strongly related to the stage at diagnosis. Therefore, early diagnosis is …

Altered glycosylation of mucin 1 (MUC1) on tumor cells compared to normal epithelial cells
was previously identified as an important antigenic modification recognized by the immune …

Introduction: Peritoneal dissemination is a particular form of malignant progression in
ovarian cancer, preceding hematogenic or lymphatic dissemination. Thus, prevention of …

Ovarian carcinoma is usually diagnosed at an advanced stage with peritoneal dissemination
and/or lymph node metastasis, and the prognosis for such advanced carcinoma is very poor …

Glycosylation changes of circulating proteins carrying the CA19-9 antigen may offer new
targets for detection methods to be explored for the diagnosis of epithelial ovarian cancer …

FUT1 is a key rate-limiting enzyme in the synthesis of Lewis y, a membrane-associated
carbohydrate antigen. The aberrant upregulation of FUT1 and Lewis y antigen is related to …