Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

With the rapid development of engineered nanomaterials for various applications, in vivo
toxicological studies for evaluating the potential hazardous effects of nanomaterials on …

Up to 99% of systemically administered nanoparticles are cleared through the liver. Within
the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells) …

Nanoparticles are becoming an increasingly popular tool for biomedical imaging and drug
delivery. While the prevalence of nanoparticle drug-delivery systems reported in the …

The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …

Zebrafish (Danio rerio) is an ideal in vivo model to study a wide variety of human cancer
types. In this review, we provide a comprehensive overview of zebrafish in the cancer drug …

Regulation of biological processes is often based on physical interactions between cells and
their microenvironment. To unravel how and where interactions occur, micromanipulation …

As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …

The enhanced permeability and retention (EPR) effect is the only described mechanism
enabling nanoparticles (NPs) flowing in blood to reach tumors by a passive targeting …

Solvatochromic dyes enable sensing and imaging of biomolecular organization in living
systems by monitoring local polarity (lipophilicity), but most such dyes suffer from limited …