Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

The inadequacy of animal models in correctly predicting drug and biothreat agent toxicity in
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …

In the pharmaceutical industry, improving the early detection of drug-induced hepatotoxicity
is essential as it is one of the most important reasons for attrition of candidate drugs during …

Background Dysfunctions of long non-coding RNA (lncRNAs) have been associated with the
initiation and progression of hepatocellular carcinoma (HCC), but the clinicopathologic …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

In addition to primary human hepatocytes, hepatoma cell lines, and transfected
nonhepatoma, hepatic cell lines have been used for pharmacological and toxicological …

Spheroid-based three-dimensional (3D) liver culture models, offering a desirable biomimetic
microenvironment, are useful for recapitulating liver functions in vitro. However, a user …

Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …

The use of silver nanoparticles in food, food contact materials, dietary supplements and
cosmetics has increased significantly owing to their antibacterial and antifungal properties …