Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products

GA Vitale, C Geibel, V Minda, M Wang, AT Aron… - Natural Product …, 2024‏ - pubs.rsc.org
Covering: 1995 to 2023 Advances in bioanalytical methods, particularly mass spectrometry,
have provided valuable molecular insights into the mechanisms of life. Non-targeted …

Accessing hidden microbial biosynthetic potential from underexplored sources for novel drug discovery

L Li - Biotechnology Advances, 2023‏ - Elsevier
Microbial natural products and their structural analogues have widely used as
pharmaceutical agents, especially for infectious diseases and cancer. Despite this success …

Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes

A Gavriilidou, SA Kautsar, N Zaburannyi, D Krug… - Nature …, 2022‏ - nature.com
Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …

Microbiome composition modulates secondary metabolism in a multispecies bacterial community

MG Chevrette, CS Thomas, A Hurley… - Proceedings of the …, 2022‏ - pnas.org
Bacterial secondary metabolites are a major source of antibiotics and other bioactive
compounds. In microbial communities, these molecules can mediate interspecies …

Cheminformatics-Guided Cell-Free Exploration of Peptide Natural Products

JM Pelton, JE Hochuli, PW Sadecki… - Journal of the …, 2024‏ - ACS Publications
There have been significant advances in the flexibility and power of in vitro cell-free
translation systems. The increasing ability to incorporate noncanonical amino acids and …

Integrated metabolomic–genomic workflows accelerate microbial natural product discovery

NE Avalon, AE Murray, BJ Baker - Analytical chemistry, 2022‏ - ACS Publications
The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …

Biogeographic patterns of biosynthetic potential and specialized metabolites in marine sediments

AB Chase, A Bogdanov, AM Demko… - The ISME …, 2023‏ - academic.oup.com
While the field of microbial biogeography has largely focused on the contributions of abiotic
factors to community patterns, the potential influence of biotic interactions in structuring …

Recent advances in genome mining and synthetic biology for discovery and biosynthesis of natural products

M Wang, L Chen, Z Zhang, Q Wang - Critical Reviews in …, 2025‏ - Taylor & Francis
Natural products have long served as critical raw materials in chemical and pharmaceutical
manufacturing, primarily which can provide superior scaffolds or intermediates for drug …

Chemophenetic and chemodiversity approaches: new insights on modern study of plant secondary metabolite diversity at different spatiotemporal and organizational …

YJ Ramos, JG Gouvêa-Silva… - Revista Brasileira de …, 2023‏ - Springer
The study of plant secondary metabolites, now designated as specialized metabolites, is
motivated by multiple scientific objectives, ranging from bioprospecting for bioactive …

[HTML][HTML] Targeted large-scale genome mining and candidate prioritization for natural product discovery

JJL Malit, HYC Leung, PY Qian - Marine drugs, 2022‏ - mdpi.com
Large-scale genome-mining analyses have identified an enormous number of cryptic
biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products …