Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

SALL4, a member of the SALL family, is an embryonic stem cell regulator involved in self-
renewal and pluripotency. Recently, SALL4 overexpression was found in malignant cancers …

Background Although hypomethylating agents are currently used to treat patients with
cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated …

Spalt-Like Transcription Factor 4 (SALL4) is a critical factor for self-renewal ability and
pluripotency of stem cells. On the other hand, various reports show tight relation of SALL4 to …

Hepatitis B virus (HBV), the well-studied oncovirus that contributes to the majority of
hepatocellular carcinomas (HCC) worldwide, can cause a severe inflammatory …

Background The unique expression pattern endows oncofetal genes with great value in
cancer diagnosis and treatment. However, only a few oncofetal genes are available for …

Simple Summary Transcription factors play essential roles in regulating gene expression,
impacting the cell phenotype and function, and in the response of cells to environmental …

A primitive cell-like gene expression signature is associated with aggressive phenotypes of
various cancers. We assessed the expression of phenotypic markers characterizing primitive …

Multiple mechanisms of epigenetic control that include DNA methylation, histone
modification, noncoding RNAs, and mitotic gene bookmarking play pivotal roles in stringent …

Abstract SALL4 (split‐like protein 4) is a member of the mammalian homologs of the
Drosophila homoeotic gene spalt (sal) and acts as a zinc finger transcription factor to govern …