[HTML][HTML] Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery
Diseases caused by parasitic helminths (worms) represent a major global health burden in
both humans and animals. As vaccines against helminths have yet to achieve a prominent …
both humans and animals. As vaccines against helminths have yet to achieve a prominent …
Identification of Anthelmintic Bishomoscalarane Sesterterpenes from the Australian Marine Sponge Phyllospongia bergquistae and Structure Revision of …
High-throughput screening of the NatureBank marine extract library (7616 samples)
identified an extract derived from the Australian marine sponge Phyllospongia bergquistae …
identified an extract derived from the Australian marine sponge Phyllospongia bergquistae …
The Proteome and Lipidome of Extracellular Vesicles from Haemonchus contortus to Underpin Explorations of Host–Parasite Cross–Talk
Many parasitic worms have a major adverse impact on human and animal populations
worldwide due to the chronicity of their infections. There is a growing body of evidence …
worldwide due to the chronicity of their infections. There is a growing body of evidence …
Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in
humans and other animals around the world. The control of these parasites relies heavily on …
humans and other animals around the world. The control of these parasites relies heavily on …
A high-throughput phenotypic screen of the 'Pandemic Response Box'identifies a quinoline derivative with significant anthelmintic activity
Parasitic nematodes cause diseases in livestock animals and major economic losses to the
agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus …
agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus …
Phytochemical profile and anthelmintic effects of Laurus nobilis essential oil against the ovine nematode Haemonchus contortus and the murine helminth model …
E Sebai, A Abidi, H Benyedem, M Dhibi… - Veterinary …, 2022 - Elsevier
Small ruminant production in tropical and temperate countries faced substantial anthelmintic
resistance due to the intensive use of commercial anthelmintic drugs. Therefore, alternative …
resistance due to the intensive use of commercial anthelmintic drugs. Therefore, alternative …
[HTML][HTML] Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans
Global challenges with treatment failures and/or widespread resistance in parasitic worms
against commercially available anthelmintics lend impetus to the development of new …
against commercially available anthelmintics lend impetus to the development of new …
Nematocidal Activity of Ethanol and Aqueous Extracts of Persea americana Seeds against Heligmosomoides polygyrus using the Worm Microtracker Method
Background. Infections with gastrointestinal helminths constitute a serious obstacle to the
good health of the local population in most African Countries. The aim of this study was to …
good health of the local population in most African Countries. The aim of this study was to …
Targeted Isolation of Antibiotic Brominated Alkaloids from the Marine Sponge Pseudoceratina durissima Using Virtual Screening and Molecular Networking
Many targeted natural product isolation approaches rely on the use of pre-existing bioactivity
information to inform the strategy used for the isolation of new bioactive compounds …
information to inform the strategy used for the isolation of new bioactive compounds …
High Throughput Screening of the NatureBank 'Marine Collection' in a Haemonchus Bioassay Identifies Anthelmintic Activity in Extracts from a Range of Sponges …
Widespread resistance in parasitic nematodes to most classes of anthelmintic drugs
demands the discovery and development of novel compounds with distinct mechanisms of …
demands the discovery and development of novel compounds with distinct mechanisms of …