From Levinthal to pathways to funnels
From Levinthalto pathways to funnels Page 1 TS 9 1997 Nature Publishing Group http://www.nature.com/nsmb
perspective From Levinthalto pathways to funnels Ken A. Dill and Hue Sun Chan A new …
perspective From Levinthalto pathways to funnels Ken A. Dill and Hue Sun Chan A new …
Principles of protein folding—a perspective from simple exact models
General principles of protein structure, stability, and folding kinetics have recently been
explored in computer simulations of simple exact lattice models. These models represent …
explored in computer simulations of simple exact lattice models. These models represent …
Funnels, pathways, and the energy landscape of protein folding: a synthesis
The understanding, and even the description of protein folding is impeded by the complexity
of the process. Much of this complexity can be described and understood by taking a …
of the process. Much of this complexity can be described and understood by taking a …
Navigating the folding routes
A theory of helix formation in collapsed polymers relates the measured amount of helix in the
collapsed states to the conformational entropy associated with different chain topologies …
collapsed states to the conformational entropy associated with different chain topologies …
Native contacts determine protein folding mechanisms in atomistic simulations
The recent availability of long equilibrium simulations of protein folding in atomistic detail for
more than 10 proteins allows us to identify the key interactions driving folding. We find that …
more than 10 proteins allows us to identify the key interactions driving folding. We find that …
Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy
The dimensions of unfolded and intrinsically disordered proteins are highly dependent on
their amino acid composition and solution conditions, especially salt and denaturant …
their amino acid composition and solution conditions, especially salt and denaturant …
Single-molecule FRET spectroscopy and the polymer physics of unfolded and intrinsically disordered proteins
The properties of unfolded proteins have long been of interest because of their importance
to the protein folding process. Recently, the surprising prevalence of unstructured regions or …
to the protein folding process. Recently, the surprising prevalence of unstructured regions or …
Nucleation mechanisms in protein folding
AR Fersht - Current opinion in structural biology, 1997 - Elsevier
Experiment and theory are converging on the importance of nucleation mechanisms in
protein folding. These mechanisms do not use classic nuclei, which are well formed …
protein folding. These mechanisms do not use classic nuclei, which are well formed …
Force-clamp spectroscopy monitors the folding trajectory of a single protein
We used force-clamp atomic force micoscopy to measure the end-to-end length of the small
protein ubiquitin during its folding reaction at the single-molecule level. Ubiquitin was first …
protein ubiquitin during its folding reaction at the single-molecule level. Ubiquitin was first …
Polymer principles and protein folding
KA Dill - Protein Science, 1999 - cambridge.org
This paper surveys the emerging role of statistical mechanics and polymer theory in protein
folding. In the polymer perspective, the folding code is more a solvation code than a code of …
folding. In the polymer perspective, the folding code is more a solvation code than a code of …