Mechanisms of regulation of the chemokine-receptor network
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …
of leukocytes during normal immune function and as a key aspect of the inflammatory …
Targeting CCL5 in inflammation
Introduction: Chemokines play important roles in inflammation and in immune responses.
This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and …
This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and …
Uncovering the trimethylamine-producing bacteria of the human gut microbiota
Background Trimethylamine (TMA), produced by the gut microbiota from dietary quaternary
amines (mainly choline and carnitine), is associated with atherosclerosis and severe …
amines (mainly choline and carnitine), is associated with atherosclerosis and severe …
Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism
Human cytomegalovirus replicates in many different cell types, including epithelial cells,
endothelial cells, and fibroblasts. However, laboratory strains of the virus, many of which …
endothelial cells, and fibroblasts. However, laboratory strains of the virus, many of which …
Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism
L Vastag, E Koyuncu, SL Grady, TE Shenk… - PLoS …, 2011 - journals.plos.org
Viruses rely on the metabolic network of the host cell to provide energy and macromolecular
precursors to fuel viral replication. Here we used mass spectrometry to examine the impact …
precursors to fuel viral replication. Here we used mass spectrometry to examine the impact …
Tuning inflammation and immunity by chemokine sequestration: decoys and more
A set of chemokine receptors are structurally unable to elicit migration or conventional
signalling responses after ligand engagement. These'silent'(non-signalling) chemokine …
signalling responses after ligand engagement. These'silent'(non-signalling) chemokine …
Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropism
Epithelial cells are one of the prominent cell types infected by human cytomegalovirus
(HCMV) within its host. However, many cultured epithelial cells, such as ARPE-19 retinal …
(HCMV) within its host. However, many cultured epithelial cells, such as ARPE-19 retinal …
[HTML][HTML] A portrait of the human organelle proteome in space and time during cytomegalovirus infection
The organelles within a eukaryotic host are manipulated by viruses to support successful
virus replication and spread of infection, yet the global impact of viral infection on host …
virus replication and spread of infection, yet the global impact of viral infection on host …
High-resolution human cytomegalovirus transcriptome
D Gatherer, S Seirafian… - Proceedings of the …, 2011 - National Acad Sciences
Deep sequencing was used to bring high resolution to the human cytomegalovirus (HCMV)
transcriptome at the stage when infectious virion production is under way, and major …
transcriptome at the stage when infectious virion production is under way, and major …
Precision mouse models with expanded tropism for human pathogens
A major limitation of current humanized mouse models is that they primarily enable the
analysis of human-specific pathogens that infect hematopoietic cells. However, most human …
analysis of human-specific pathogens that infect hematopoietic cells. However, most human …