Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …

In neurons, but also in all other cells the complex proteostasis network is monitored and
tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly …

Macroautophagy/autophagy is a conserved catabolic recycling pathway in which
cytoplasmic components are sequestered, degraded, and recycled to survive various stress …

Target-specific treatment modalities are currently not available for triple-negative breast
cancer (TNBC), and acquired chemotherapy resistance is a primary obstacle for the …

Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore,
understanding the mechanisms underlying the removal of dysfunctional mitochondria from …

Abstract Bcl-2 associated athanogene 3 (BAG3) is an important molecule that maintains
oncogenic features of cancer cells via diverse mechanisms. One of the important functions …

Background Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer,
becoming the most mortality of all cancers globally. Blockage of autophagy in NSCLC …

Autophagy is a cellular quality control and energy-providing process that is under strict
control by intra-and extracellular stimuli. Recently, there has been an exponential increase …

Background The contribution of native or modified oligodendroglia-derived extracellular
vesicles (OL-EVs) in controlling chronic inflammation is poorly understood. In activated …

The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most
prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it …