YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

Wnt/beta-catenin pathway: modulating anticancer immune response

SG Pai, BA Carneiro, JM Mota, R Costa… - Journal of hematology & …, 2017 - Springer
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key
cellular functions including proliferation, differentiation, migration, genetic stability …

YAP aggravates inflammatory bowel disease by regulating M1/M2 macrophage polarization and gut microbial homeostasis

X Zhou, W Li, S Wang, P Zhang, Q Wang, J **ao… - Cell reports, 2019 - cell.com
Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial
homeostasis are critical for the pathological processes associated with inflammatory bowel …

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation

R LaCanna, D Liccardo, P Zhang, L Tragesser… - The Journal of clinical …, 2019 - jci.org
Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …

The Hippo pathway and human cancer

KF Harvey, X Zhang, DM Thomas - Nature Reviews Cancer, 2013 - nature.com
The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

YAP/TAZ signaling as a molecular link between fibrosis and cancer

S Noguchi, A Saito, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

R Johnson, G Halder - Nature reviews Drug discovery, 2014 - nature.com
The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …

YAP and TAZ: a nexus for Hippo signaling and beyond

CG Hansen, T Moroishi, KL Guan - Trends in cell biology, 2015 - cell.com
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …

A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer

S Jiao, H Wang, Z Shi, A Dong, W Zhang, X Song, F He… - Cancer cell, 2014 - cell.com
The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators …

Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity

R Ding, Y Chen, X Shi, Y Li, Y Yu, Z Sun… - Science of The Total …, 2024 - Elsevier
Abstract Microplastics (MPs) and nanoplastics (NPs) have been generally regarded as
emerging pollutants and received worldwide attention in recent years. Water and food …