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YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
Wnt/beta-catenin pathway: modulating anticancer immune response
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key
cellular functions including proliferation, differentiation, migration, genetic stability …
cellular functions including proliferation, differentiation, migration, genetic stability …
YAP aggravates inflammatory bowel disease by regulating M1/M2 macrophage polarization and gut microbial homeostasis
X Zhou, W Li, S Wang, P Zhang, Q Wang, J **ao… - Cell reports, 2019 - cell.com
Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial
homeostasis are critical for the pathological processes associated with inflammatory bowel …
homeostasis are critical for the pathological processes associated with inflammatory bowel …
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation
R LaCanna, D Liccardo, P Zhang, L Tragesser… - The Journal of clinical …, 2019 - jci.org
Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …
The Hippo pathway and human cancer
The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …
can induce tumours in model organisms and occurs in a broad range of human carcinomas …
YAP/TAZ signaling as a molecular link between fibrosis and cancer
S Noguchi, A Saito, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …
YAP and TAZ: a nexus for Hippo signaling and beyond
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …
A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer
The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators …
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators …
Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity
R Ding, Y Chen, X Shi, Y Li, Y Yu, Z Sun… - Science of The Total …, 2024 - Elsevier
Abstract Microplastics (MPs) and nanoplastics (NPs) have been generally regarded as
emerging pollutants and received worldwide attention in recent years. Water and food …
emerging pollutants and received worldwide attention in recent years. Water and food …