Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration …

Oxylipins are potent biological mediators requiring strict control, but how they are removed
en masse during infection and inflammation is unknown. Here we show that …

Macrophages play an important role in the adaptive immune system. Their ability to
neutralize cellular targets through Fc receptor‐mediated phagocytosis has relied upon …

Genetic association studies have identified multiple variants at the SPI1 locus that modify
risk and age of onset for Alzheimer's Disease (AD). Reports linking risk variants to gene …

Recent interest in the biology and function of peritoneal tissue resident macrophages (pMΦ)
has led to a better understanding of their cellular origin, programming, and renewal. The …

Macrophages are critical players in the development of atherosclerotic lesions, where they
promote local and systemic inflammation. Macrophages engulf lipoproteins and cell debris …

Develo** new strategies for local monitoring and delivery of immunosuppression is critical
to making allografts safer and more accessible. Ex vivo genetic modification of grafts using …

Simple Summary The mammalian peritoneal cavity harbors the liver, spleen, most of the
gastrointestinal tract and other viscera, and is a dynamic microenvironment involved in …

Peritoneal tissue-resident macrophages have broad functions in the maintenance of
homeostasis and are involved in pathologies within local and neighboring tissues. Their …

Advanced age is the greatest risk factor for the most devastating diseases of our time,
including cancer, neurodegeneration, and cardiovascular disease. A better understanding of …