Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

Electrochemistry represents one of the most intimate ways of interacting with molecules. This
review discusses advances in synthetic organic electrochemistry since 2000. Enabling …

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …

Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Electrochemical transition metal catalysis is a powerful strategy for organic synthesis
because it obviates the use of stoichiometric chemical oxidants and reductants. C–H bond …

The “magic methyl” effect, a dramatic boost in the potency of biologically active compounds
from the incorporation of a single methyl group, provides a simple yet powerful strategy …

Electrosynthesis has much to offer to the synthetic organic chemist. But in order to be widely
accepted as a routine procedure in an organic synthesis laboratory, electrosynthesis needs …

Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …

Organic synthesis is changing; in a world where budgets are constrained and the
environmental impacts of practice are scrutinized, it is increasingly recognized that the …

The field of flow chemistry has garnered considerable attention over the past 2 decades.
This Perspective highlights many recent advances in the field of flow chemistry and …