From early life to adulthood, the microbiota play a crucial role in the health of the infant. The
microbiota in early life are not only a key regulator of infant health but also associated with …

The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …

The mammalian gut microbial community, known as the gut microbiota, comprises trillions of
bacteria, which co-evolved with the host and has an important role in a variety of host …

Gamma-aminobutyric acid (GABA) plays a crucial role in the central nervous system as an
inhibitory neurotransmitter. Imbalances of this neurotransmitter are associated with …

The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …

The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …

The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …

The human gut microbiome plays a key role in human health 1, but 16S characterization
lacks quantitative functional annotation 2. The fecal metabolome provides a functional …

Human diseases are increasingly linked with an altered or" dysbiotic" gut microbiota, but
whether such changes are causal, consequential, or bystanders to disease is, for the most …

Although humans have cospeciated with their gut-resident microbes, it is difficult to infer
features of our ancestral microbiome. Here, we examine the microbiome profile of 350 stool …