Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)

C Yap, A Mieremet, CJM de Vries, D Micha… - … , and vascular biology, 2021 - ahajournals.org
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

A Frismantiene, M Philippova, P Erne, TJ Resink - Cellular signalling, 2018 - Elsevier
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction)

DA Chistiakov, AN Orekhov, YV Bobryshev - Journal of molecular and …, 2016 - Elsevier
Abstract Cardiac miRNAs (miR-1, miR133a, miR-208a/b, and miR-499) are abundantly
expressed in the myocardium. They play a central role in cardiogenesis, heart function and …

Origin and differentiation of vascular smooth muscle cells

G Wang, L Jacquet, E Karamariti… - The Journal of …, 2015 - Wiley Online Library
Vascular smooth muscle cells (SMCs), a major structural component of the vessel wall, not
only play a key role in maintaining vascular structure but also perform various functions …

Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1

F Jiang, Q Chen, W Wang, Y Ling, Y Yan, P **a - Journal of Hepatology, 2020 - Elsevier
Background & Aims Clinical evidence has indicated a close link between non-alcoholic fatty
liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying …

Impact of miRNA in atherosclerosis

Y Lu, T Thavarajah, W Gu, J Cai… - … , thrombosis, and vascular …, 2018 - ahajournals.org
e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …

Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation

BN Davis-Dusenbery, C Wu, A Hata - … , thrombosis, and vascular …, 2011 - ahajournals.org
The phenotype of vascular smooth muscle cells (VSMCs) is dynamically regulated in
response to various stimuli. In a cellular process known as phenotype switching, VSMCs …

microRNAs: important regulators of stem cells

N Li, B Long, W Han, S Yuan, K Wang - Stem cell research & therapy, 2017 - Springer
Stem cells are undifferentiated cells and have multi-lineage differentiation potential.
Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and …

Down-regulation of Krüppel-like Factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth …

BN Davis-Dusenbery, MC Chan, KE Reno… - Journal of Biological …, 2011 - jbc.org
In the postnatal vasculature, fully differentiated and quiescent vascular smooth muscle cells
(VSMCs) in a" contractile" phenotype are required for the normal regulation of vascular tone …