Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that
are increasingly recognized to be essential players in the development, homeostasis and …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and
tissue repair. However, molecular pathways that govern their differentiation have remained …

Microglia, the brain-resident immune cells, are critically involved in many physiological and
pathological brain processes, including neurodegeneration. Here we characterize microglia …

Lung development and function arises from the interactions between diverse cell types and
lineages. Using single-cell RNA sequencing (RNA-seq), we characterize the cellular …

Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Infiltration by immune cells is a hallmark of most forms of malignancy. In this context, tumor-
associated macrophages (TAMs) represent key regulators of the complex interplay between …

Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs)
family, is located downstream of the pattern recognition receptors (PRRs)-mediated …

The central nervous system (CNS) and its meningeal coverings accommodate a diverse
myeloid compartment that includes parenchymal microglia and perivascular macrophages …