Mediating kinase activity in Ras-mutant cancer: potential for an individualised approach?
FM Healy, AL Turner, V Marensi… - Frontiers in …, 2024 - frontiersin.org
It is widely acknowledged that there is a considerable number of oncogenic mutations within
the Ras superfamily of small GTPases which are the driving force behind a multitude of …
the Ras superfamily of small GTPases which are the driving force behind a multitude of …
Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)
KM Zak, AG Waterson, L Geist, N Braun… - Journal of Medicinal …, 2025 - ACS Publications
The Son of Sevenless (SOS) protein family includes two highly homologous proteins, SOS1
and SOS2, that act as guanine nucleotide exchange factors (GEFs) for RAS proteins. They …
and SOS2, that act as guanine nucleotide exchange factors (GEFs) for RAS proteins. They …
The Potential Treatment Options and Combination Strategies of KRAS-Mutated Lung Cancer
X Zhao, Y Zheng, Y Wang, M Zhang… - OncoTargets and …, 2024 - Taylor & Francis
In non-small cell lung cancer (NSCLC), Kirsten rat sarcoma viral oncogene homolog (KRAS)
mutations are found in up to 30% of all cases, with the most prevalent mutations occurring in …
mutations are found in up to 30% of all cases, with the most prevalent mutations occurring in …