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An introduction to mass spectrometry-based proteomics
Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …
proteome. Because the foundations of mass spectrometry-based proteomics are complex …
Adding intrinsically disordered proteins to biological ageing clocks
Research into how the young and old differ, and which biomarkers reflect the diverse
biological processes underlying ageing, is a current and fast-growing field. Biological clocks …
biological processes underlying ageing, is a current and fast-growing field. Biological clocks …
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
S Lee, NA Devanney, LR Golden, CT Smith… - Cell reports, 2023 - cell.com
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …
a heightened pro-inflammatory response: two findings that may be intrinsically linked …
Versican promotes cardiomyocyte proliferation and cardiac repair
BACKGROUND: The adult mammalian heart is incapable of regeneration, whereas a
transient regenerative capacity is maintained in the neonatal heart, primarily through the …
transient regenerative capacity is maintained in the neonatal heart, primarily through the …
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …
represents an ever‐expanding focus in the development of proteomics. As mass …
Costs and Benefits of Popular P-Value Correction Methods in Three Models of Quantitative Omic Experiments
The multiple hypothesis testing problem is inherent in large-scale quantitative “omic”
experiments such as mass spectrometry-based proteomics. Yet, tools for comparing the …
experiments such as mass spectrometry-based proteomics. Yet, tools for comparing the …
The choroid plexus maintains adult brain ventricles and subventricular zone neuroblast pool, which facilitates poststroke neurogenesis
The brain's neuroreparative capacity after injuries such as ischemic stroke is partly
contained in the brain's neurogenic niches, primarily the subventricular zone (SVZ), which …
contained in the brain's neurogenic niches, primarily the subventricular zone (SVZ), which …
Global analysis of aging-related protein structural changes uncovers enzyme-polymerization-based control of longevity
Aging is associated with progressive phenotypic changes. Virtually all cellular phenotypes
are produced by proteins, and their structural alterations can lead to age-related diseases …
are produced by proteins, and their structural alterations can lead to age-related diseases …
FLiPPR: a processor for limited proteolysis (LiP) mass spectrometry data sets built on FragPipe
Here, we present FLiPPR, or FragPipe LiP (limited proteolysis) Processor, a tool that
facilitates the analysis of data from limited proteolysis mass spectrometry (LiP-MS) …
facilitates the analysis of data from limited proteolysis mass spectrometry (LiP-MS) …
[HTML][HTML] Navigating the Neuroimmunomodulation Frontier: Pioneering Approaches and Promising Horizons—A Comprehensive Review
The research in neuroimmunomodulation aims to shed light on the complex relationships
that exist between the immune and neurological systems and how they affect the human …
that exist between the immune and neurological systems and how they affect the human …