Splicing regulation through biomolecular condensates and membraneless organelles
Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …
Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology
Quantifying the mechanical response of the biological milieu (such as the cell's interior) and
complex fluids (such as biomolecular condensates) would enable a better understanding of …
complex fluids (such as biomolecular condensates) would enable a better understanding of …
Conformational ensembles of the human intrinsically disordered proteome: Bridging chain compaction with function and sequence conservation
Intrinsically disordered proteins and regions (collectively IDRs) are pervasive across
proteomes in all kingdoms of life, help shape biological functions, and are involved in …
proteomes in all kingdoms of life, help shape biological functions, and are involved in …
A pH-Dependent Coarse-Grained Model for Disordered Proteins: Histidine Interactions Modulate Conformational Ensembles
Histidine (His) presents a unique challenge for modeling disordered protein conformations,
as it is versatile and occurs in both the neutral (His0) and positively charged (His+) states …
as it is versatile and occurs in both the neutral (His0) and positively charged (His+) states …
Accurate long-read transcript discovery and quantification at single-cell, pseudo-bulk and bulk resolution with Isosceles
Accurate detection and quantification of mRNA isoforms from nanopore long-read
sequencing remains challenged by technical noise, particularly in single cells. To address …
sequencing remains challenged by technical noise, particularly in single cells. To address …
Core-shell model of the clusters of CPEB4 isoforms preceding liquid-liquid phase separation
Protein solutions can undergo liquid-liquid phase separation (LLPS), where a dispersed
phase with a low protein concentration coexists with coacervates with a high protein …
phase with a low protein concentration coexists with coacervates with a high protein …
Cytoplasmic Regulation of the Poly (A) Tail Length as a Potential Therapeutic Target
M Fernandez, R Mendez - RNA, 2025 - rnajournal.cshlp.org
Virtually all mRNAs acquire a poly (A) tail co-transcriptionally, but its length is dynamically
regulated in the cytoplasm in a transcript-specific manner. The length of the poly (A) tail …
regulated in the cytoplasm in a transcript-specific manner. The length of the poly (A) tail …
[HTML][HTML] Metastable condensates suppress conversion to amyloid fibrils
Stress granules form via co-condensation of RNA binding proteins with prion-like low
complexity domains (PLCDs) and RNA molecules released by stress-induced polysomal …
complexity domains (PLCDs) and RNA molecules released by stress-induced polysomal …
Microexon in action: How tiny fragments in a protein tune function, drive disease
J Huang - Molecular Cell, 2025 - cell.com
Intrinsically disordered regions (IDRs) of proteins can regulate function through phase
separation. In a recent article in Nature, Garcia-Cabau et al. reveal that including or …
separation. In a recent article in Nature, Garcia-Cabau et al. reveal that including or …
Measuring age-dependent viscoelastic properties of organelles, cells and organisms via Time-Shared Optical Tweezer Microrheology
Recording the mechanical response of biological samples, the cell's interior and complex
fluids in general, would enable deeper understanding of cellular differentiation, ageing and …
fluids in general, would enable deeper understanding of cellular differentiation, ageing and …