The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has
received increasing attention in recent years, and its safety and high efficiency have …

Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Recent clinical trials have demonstrated a clear survival advantage in advanced head and
neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade …

Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic
function that provide host defence against microbial infection and tumours. Here, we review …

Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …

The immune system plays important roles in tumor development. According to the immune-
editing theory, immune escape is the key to tumor survival, and exploring the mechanisms of …

Tertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer
(NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR+ innate …

Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK
cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of …