Sarcopenia is the age‐related decline in muscle mass and function without any underlying
disease. The exact molecular mechanisms responsible for this pathology remain unknown …

Exercise is a robust stimulus for mitochondrial adaptations in skeletal muscle which
consequently plays a central role in enhancing metabolic health. Despite this, the precise …

Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …

Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular
nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR …

Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …

Background Exercise exerts remarkably powerful effects on metabolism and health, with anti-
disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits …

Regular physical exercise is the most efficient and accessible intervention known to promote
healthy aging in humans. The molecular and cellular mechanisms that mediate system-wide …

In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

In this study, we report a microfluidic device for the whole-life culture of the nematode
Caenorhabditis elegans that allows the scoring of animal survival and health measures. This …

The nematode C. elegans (worm) is a small invertebrate animal widely used in studies
related to fundamental biological processes, disease modelling, and drug discovery. Due to …