The integration and control of systemic immune responses depends on the regulated
trafficking of lymphocytes. This lymphocyte “homing” process disperses the immunologic …

The delicate microenvironment of the central nervous system (CNS) is protected by the
blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). These barriers …

High endothelial venules (HEVs? are specialized postcapillary venules found in lymphoid
tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean …

Reports on the migration of leucocytes throughout the body to mediate immune surveillance
and to mount inflammatory responses to foreign antigens. Sequential steps in adhesion of …

During embryonic development, endothelial cells differentiate from a common precursor
called angioblast and acquire organ-specific properties. One of the important determinants …

Many long noncoding RNAs (lncRNAs) are reported to be dysregulated in human cancers
and play critical roles in tumor development and progression. Furthermore, it has been …

A hallmark feature of inflammation is the orchestrated recruitment of neutrophils from the
bloodstream into inflamed tissue. Although selectins and integrins mediate recruitment in …

Vascular adhesion protein 1 (VAP-1) is a human endothelial sialoglycoprotein whose cell
surface expression is induced under inflammatory conditions. It has been shown previously …

Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …

Leukocyte interactions with vascular endothelium at sites of inflammation can be
dynamically regulated by activation-dependent adhesion molecules. Current models …