Beyond the RNA-dependent function of LncRNA genes
While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the last
decade, the focus regarding their mechanisms of action has been primarily on the RNA …
decade, the focus regarding their mechanisms of action has been primarily on the RNA …
3′ UTR heterogeneity and cancer progression
JJ Chan, H Tabatabaeian, Y Tay - Trends in Cell Biology, 2023 - cell.com
The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …
through various processes, including RNA modifications such as RNA editing, m 6 A …
Exon architecture controls mRNA m6A suppression and gene expression
N 6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation
Sequence-based machine-learning models trained on genomics data improve genetic
variant interpretation by providing functional predictions describing their impact on the cis …
variant interpretation by providing functional predictions describing their impact on the cis …
High-throughput total RNA sequencing in single cells using VASA-seq
Most methods for single-cell transcriptome sequencing amplify the termini of polyadenylated
transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes …
transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes …
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
Mutations causing amyotrophic lateral sclerosis (ALS) often affect the condensation
properties of RNA-binding proteins (RBPs). However, the role of RBP condensation in the …
properties of RNA-binding proteins (RBPs). However, the role of RBP condensation in the …
Long 3′ UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation
Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory
diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly …
diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly …
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue
Single-nuclei RNA sequencing characterizes cell types at the gene level. However,
compared to single-cell approaches, many single-nuclei cDNAs are purely intronic, lack …
compared to single-cell approaches, many single-nuclei cDNAs are purely intronic, lack …
A spatially resolved brain region-and cell type-specific isoform atlas of the postnatal mouse brain
Splicing varies across brain regions, but the single-cell resolution of regional variation is
unclear. We present a single-cell investigation of differential isoform expression (DIE) …
unclear. We present a single-cell investigation of differential isoform expression (DIE) …
SQANTI3: curation of long-read transcriptomes for accurate identification of known and novel isoforms
SQANTI3 is a tool designed for the quality control, curation and annotation of long-read
transcript models obtained with third-generation sequencing technologies. Leveraging its …
transcript models obtained with third-generation sequencing technologies. Leveraging its …