Radiopharmaceutical therapy in cancer: clinical advances and challenges
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …
Astatine-211 based radionuclide therapy: Current clinical trial landscape
P Albertsson, T Bäck, K Bergmark, A Hallqvist… - Frontiers in …, 2023 - frontiersin.org
Astatine-211 (211At) has physical properties that make it one of the top candidates for use
as a radiation source for alpha particle-based radionuclide therapy, also referred to as …
as a radiation source for alpha particle-based radionuclide therapy, also referred to as …
Targeted α-therapy of metastatic castration-resistant prostate cancer with 225Ac-PSMA-617: swimmer-plot analysis suggests efficacy regarding duration of tumor …
C Kratochwil, F Bruchertseifer, H Rathke… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The aim of this evaluation was to identify the first indicators of efficacy for 225Ac-labeled
prostate-specific membrane antigen (PSMA)–617 therapy in a retrospectively analyzed …
prostate-specific membrane antigen (PSMA)–617 therapy in a retrospectively analyzed …
Targeted α-therapy of metastatic castration-resistant prostate cancer with 225Ac-PSMA-617: dosimetry estimate and empiric dose finding
C Kratochwil, F Bruchertseifer, H Rathke… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The aim of this study was to develop a treatment protocol for 225Ac-PSMA-617 α-radiation
therapy in advanced-stage, metastatic castration-resistant prostate cancer patients with …
therapy in advanced-stage, metastatic castration-resistant prostate cancer patients with …
225Ac-PSMA-617 for therapy of prostate cancer
C Kratochwil, U Haberkorn, FL Giesel - Seminars in nuclear medicine, 2020 - Elsevier
Prostate-specific membrane antigen (PSMA)-targeting radio-ligand therapy with beta-
emitting 177 Lutetium has already been investigated in several early phase dosimetry …
emitting 177 Lutetium has already been investigated in several early phase dosimetry …
Preclinical efficacy of a PSMA-targeted thorium-227 conjugate (PSMA-TTC), a targeted alpha therapy for prostate cancer
S Hammer, UB Hagemann, S Zitzmann-Kolbe… - Clinical Cancer …, 2020 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is an attractive target for radionuclide
therapy of metastatic castration-resistant prostate cancer (mCRPC). PSMA-targeted alpha …
therapy of metastatic castration-resistant prostate cancer (mCRPC). PSMA-targeted alpha …
Current status of theranostics in prostate cancer
The aim of this review is to report on the current status of prostate-specific membrane
antigen (PSMA)-directed theranostics in prostate cancer (PC) patients. The value of 68 Ga …
antigen (PSMA)-directed theranostics in prostate cancer (PC) patients. The value of 68 Ga …
Preclinical and clinical status of PSMA-targeted alpha therapy for metastatic castration-resistant prostate cancer
A Juzeniene, VY Stenberg, ØS Bruland, RH Larsen - Cancers, 2021 - mdpi.com
Simple Summary Currently, there is no treatment that can cure patients with late stage
metastatic prostate cancer. Prostate-specific membrane antigen is a type of protein …
metastatic prostate cancer. Prostate-specific membrane antigen is a type of protein …
Alpha-emitters and targeted alpha therapy in oncology: from basic science to clinical investigations
Alpha-emitters are radionuclides that decay through the emission of high linear energy
transfer α-particles and possess favorable pharmacologic profiles for cancer treatment …
transfer α-particles and possess favorable pharmacologic profiles for cancer treatment …
Targeted radionuclide therapy of prostate cancer—from basic research to clinical perspectives
M Czerwińska, A Bilewicz, M Kruszewski… - Molecules, 2020 - mdpi.com
Prostate cancer is the most commonly diagnosed malignancy in men and the second
leading cause of cancer-related deaths in Western civilization. Although localized prostate …
leading cause of cancer-related deaths in Western civilization. Although localized prostate …