Overcoming barriers for siRNA therapeutics: from bench to bedside
The RNA interference (RNAi) pathway possesses immense potential in silencing any gene
in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of …
in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of …
Approaches for evaluation of novel CPP-based cargo delivery systems
Cell penetrating peptides (CPPs) can be broadly defined as relatively short synthetic, protein
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …
Dual-responsive polyplexes with enhanced disassembly and endosomal escape for efficient delivery of siRNA
Despite the extracellular barriers for siRNA delivery have been overcome by utilizing
advanced nanoparticle delivery systems, the key intracellular barriers after internalization …
advanced nanoparticle delivery systems, the key intracellular barriers after internalization …
Targeted delivery of antisense oligonucleotides using neurotensin peptides
M Nikan, M Tanowitz, CA Dwyer… - Journal of Medicinal …, 2020 - ACS Publications
Despite recent advances, targeted delivery of therapeutic oligonucleotide to extra-hepatic
tissues continues to be a challenging endeavor and efficient ligand–receptor systems need …
tissues continues to be a challenging endeavor and efficient ligand–receptor systems need …
Peptide-based nanoparticles for systemic extrahepatic delivery of therapeutic nucleotides
SA Wickline, KK Hou, H Pan - International journal of molecular sciences, 2023 - mdpi.com
Peptide-based nanoparticles (PBN) for nucleotide complexation and targeting of
extrahepatic diseases are gaining recognition as potent pharmaceutical vehicles for fine …
extrahepatic diseases are gaining recognition as potent pharmaceutical vehicles for fine …
Surface-engineered mucus penetrating nucleic acid delivery systems with cell penetrating peptides for the lungs
Nucleic acids, both DNA and small RNAs, have emerged as potential therapeutics for the
treatment of various lung disorders. However, delivery of nucleic acids to the lungs is …
treatment of various lung disorders. However, delivery of nucleic acids to the lungs is …
Comparison of six cell penetrating peptides with different properties for in vitro and in vivo delivery of HPV16 E7 antigen in therapeutic vaccines
S Shahbazi, A Bolhassani - International Immunopharmacology, 2018 - Elsevier
The high risk human papillomavirus (HPV) types 16 and 18 are globally linked to> 50% and
20% of all cervical cancers, respectively. The HPV E7 oncoprotein was determined as a …
20% of all cervical cancers, respectively. The HPV E7 oncoprotein was determined as a …
Peptide carriers to the rescue: overcoming the barriers to siRNA delivery for cancer treatment
JC Cummings, H Zhang, A Jakymiw - Translational Research, 2019 - Elsevier
Cancer is a significant health concern worldwide and its clinical treatment presents many
challenges. Consequently, much research effort has focused on the development of new …
challenges. Consequently, much research effort has focused on the development of new …
[HTML][HTML] Beyond Transduction: Anti-Inflammatory Effects of Cell Penetrating Peptides
One of the bottlenecks to bringing new therapies to the clinic has been a lack of vectors for
delivering novel therapeutics in a targeted manner. Cell penetrating peptides (CPPs) have …
delivering novel therapeutics in a targeted manner. Cell penetrating peptides (CPPs) have …
[HTML][HTML] Co-localization of crotamine with internal membranes and accentuated accumulation in tumor cells
NC Mambelli-Lisboa, JM Sciani… - Molecules, 2018 - mdpi.com
Crotamine is a highly cationic; cysteine rich, cross-linked, low molecular mass cell
penetrating peptide (CPP) from the venom of the South American rattlesnake. Potential …
penetrating peptide (CPP) from the venom of the South American rattlesnake. Potential …