One of the long-standing goals of both researchers and oncologists is to establish a
framework for the complete cure of cancer with less toxic adverse effect and improved …

Background Fluorescence-guided surgery (FGS) is a technique used to enhance
visualization of tumor margins in order to increase the extent of tumor resection in glioma …

Object The extent of resection (EOR) is a known prognostic factor in patients with
glioblastoma. However, gross-total resection (GTR) is not always achieved. Understanding …

Importance High-grade gliomas (HGG) are the most aggressive and common malignant
brain tumors in adults. They have a dismally fatal prognosis. Even if gross total resection of …

OBJECTIVE Only one phase III prospective randomized study, published in 2006, has
assessed the performance of 5-aminolevulinic acid (5-ALA) fluorescence–guided surgery …

Purpose The extent of resection (EOR) is an independent prognostic factor for overall
survival (OS) in adult patients with Glioma Grade 4 (GG4). The aim of the neuro-oncology …

Background: High-grade glioma (HGG) is associated with a dismal prognosis despite
significant advances in adjuvant therapies, including chemotherapy, immunotherapy, and …

We analyzed the efficacy and applicability of surgery guided by 5-aminolevulinic acid (ALA)
fluorescence in consecutive patients with glioblastoma multiforme (GBM). Thirty-six patients …

Object Map** and monitoring are believed to provide an early warning sign to determine
when to stop tumor removal to avoid mechanical damage to the corticospinal tract (CST) …

Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of
high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5 …