Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …

SUMMARY The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the
repair of double-stranded DNA breaks by homologous recombination. It also degrades …

The repair of DNA double-strand breaks by homologous recombination commences by
nucleolytic degradation of the 5′-terminated strand of the DNA break. This leads to the …

Helicases and nucleic acid translocases are motor proteins that have essential roles in
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …

Cellular DNA is continuously engaged in a molecular dance with many accessory proteins.
These proteins are responsible for orchestrating the storage, maintenance, and transfer of …

The ability of proteins to locate specific target sequences or structures among a vast excess
of nonspecific DNA is a fundamental property that affects virtually all aspects of biology …

In bacteria, the processing of double-strand DNA breaks is mediated by the RecBCD,
AddAB and AdnAB complexes. These multisubunit helicase–nuclease machines resect the …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

In physiological settings, nucleic-acid translocases must act on substrates occupied by other
proteins, and an increasingly appreciated role of translocases is to catalyse protein …