Maltreatment-related childhood adversity is the leading preventable risk factor for mental
illness and substance abuse. Although the association between maltreatment and …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy,
childhood, adolescence, adulthood or aging, has an impact on brain structures involved in …

This highly influential work--now in a revised and expanded third edition incorporating major
advances in the field--gives clinicians, educators, and students a new understanding of what …

Rationale The investigation of putative effects of early life stress (ELS) in humans on later
behavior and neurobiology is a fast develo** field. While epidemiological and …

Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Allostasis, the concept of maintaining stability through change, has been proposed as a term
and a model to replace the ambiguous term of stress, the concept of adequately or …

Early adolescent substance use dramatically increases the risk of lifelong substance use
disorder (SUD). An adolescent sensitive period evolved to allow the development of risk …

In this paper, we provide an overview of how the maturation of specific brain regions and
stress exposure during windows of vulnerability initiate a series of events that render …

Childhood maltreatment or abuse is a major risk factor for mood, anxiety, substance abuse,
psychotic, and personality disorders, and it is associated with reduced adult hippocampal …