Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Autophagy is a mechanism that exists in all eukaryotes under a variety of physiological and
pathological conditions. In the mammalian ovaries, less than 1% of follicles ovulate …

Nobiletin is a polymethoxylated flavonoid isolated from citrus fruits with wide biological
effects, including inhibition of reactive oxygen species (ROS) production and cell cycle …

During mammalian oocyte maturation there are marked changes in the distribution of
mitochondria that supply the majority of the cellular ATP. Such redistribution of mitochondria …

Among the components of the female reproductive tract, the ovarian pool of follicles and
their enclosed oocytes are highly sensitive to hyperthermia. Heat-induced alterations in …

The ability of an oocyte to undergo successful cytoplasmic and nuclear maturation,
fertilization and embryo development is referred to as the oocyte's quality or developmental …

Female fertility relies on successful egg development. Besides chromosome segregation,
complex structural and biochemical changes in the cytoplasmic compartment are necessary …

Metabolic studies of mammalian embryos started with the development of in vitro culture
systems more than 40 years ago. More recently, metabolic studies have begun to shed light …

Melatonin is a well‐characterized antioxidant that has been successfully used to protect
oocytes from reactive oxygen species during in vitro maturation (IVM), resulting in improved …

Assisted reproduction technology (ART) has become an attractive option for infertility
treatment and holds tremendous promise. However, at present, there is still room for …