To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …

Fourth generation biofuel (FGB) uses genetically modified (GM) algae to enhance biofuel
production. Although GM algae biofuel is a well-known alternative to fossil fuels, the …

Genetically modified microorganisms (GMMs) can enable a wide range of important
applications including environmental sensing and responsive engineered living materials …

Phenylketonuria (PKU) is a genetic disease that is characterized by an inability to
metabolize phenylalanine (Phe), which can result in neurotoxicity. To provide a potential …

Biocontainment systems that couple environmental sensing with circuit-based control of cell
viability could be used to prevent escape of genetically modified microbes into the …

The increasing use of engineered organisms for industrial, clinical, and environmental
applications poses a growing risk of spreading hazardous biological entities into the …

Whole cell microbial biosensors are offering an alternative means for rapid, on-site heavy
metal detection. Based in microorganisms, biosensing constructs are designed and …

Technologies to profoundly engineer biology are becoming increasingly affordable,
powerful, and accessible to a widening group of actors. While offering tremendous potential …

The evolutionary stability of synthetic genetic circuits is key to both the understanding and
application of genetic control elements. One useful but challenging situation is a switch …

Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …