G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Breast cancer is one of the leading causes of cancer related deaths worldwide. Breast
cancer-related mortality is associated with the development of metastatic potential of primary …

The chemokine receptor CXCR4 is a widely expressed G protein-coupled receptor that has
been implicated in a number of diseases including human immunodeficiency virus, cancer …

There is an emerging interest in applying inorganic and organometallic transition metal
complexes to biomolecular and cellular studies. The cytotoxic effects of these complexes on …

Despite great potential, delivery remains as the most significant barrier to the widespread
use of siRNA therapeutics. siRNA has delivery limitations due to susceptibility to RNase …

Aims Angiotensin-converting enzyme 2 (ACE2) is a critical component of the compensatory
renin–angiotensin system that is down-regulated during the development of hypertension …

Adoptive transfer of natural killer (NK) cells can induce remission in patients with
relapsed/refractory leukemia and myeloma. However, to date, clinical efficacy of NK cell …