Pathogenesis and treatment of primary aldosteronism

MC Zennaro, S Boulkroun… - Nature Reviews …, 2020 - nature.com
Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

Diabetes mellitus secondary to endocrine diseases: an update of diagnostic and treatment particularities

MS Popoviciu, L Paduraru, RM Nutas, AM Ujoc… - International Journal of …, 2023 - mdpi.com
Secondary diabetes mellitus is frequently ignored in specialized literature. In this narrative
review, the main endocrinopathies accompanied by increased glycemic values are …

The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline

JW Funder, RM Carey, F Mantero… - The Journal of …, 2016 - academic.oup.com
Objective: To develop clinical practice guidelines for the management of patients with
primary aldosteronism. Participants: The Task Force included a chair, selected by the …

[HTML][HTML] 2022 Guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the management of hypertension

TD Wang, CE Chiang, TH Chao, HM Cheng… - Acta Cardiologica …, 2022 - ncbi.nlm.nih.gov
Hypertension is the most important modifiable cause of cardiovascular (CV) disease and all-
cause mortality worldwide. Despite the positive correlations between blood pressure (BP) …

Left ventricular remodeling and dysfunction in primary aldosteronism

CH Tsai, CT Pan, YY Chang, ZW Chen… - Journal of Human …, 2021 - nature.com
Primary aldosteronism (PA) is a common cause of secondary hypertension and is
associated with worse cardiovascular outcomes. The elevated aldosterone in PA leads to …

Cardiovascular outcomes and all-cause mortality in primary aldosteronism after adrenalectomy or mineralocorticoid receptor antagonist treatment: a meta-analysis

SY Chen, JY Chen, WC Huang… - European Journal of …, 2022 - academic.oup.com
Background In patients with primary aldosteronism (PA), long-term cardiovascular and
mortality outcomes after adrenalectomy vs mineralocorticoid receptor antagonist (MRA) …

The link between adipose tissue renin-angiotensin-aldosterone system signaling and obesity-associated hypertension

MTJ Schütten, AJHM Houben, PW de Leeuw… - …, 2017 - journals.physiology.org
Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …

Long term outcome of aldosteronism after target treatments

VC Wu, SM Wang, CH Chang, YH Hu, LY Lin… - Scientific Reports, 2016 - nature.com
There exists a great knowledge gap in terms of long-term effects of various surgical and
pharmacological treatments on outcomes among primary aldosteronism (PA) patients. Using …

IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis

CH Chou, CS Hung, CW Liao, LH Wei… - Cardiovascular …, 2018 - academic.oup.com
Aims An excess of aldosterone results in cardiac remodelling and fibrosis. Interleukin-6 (IL-
6) is a key mediator in the fibrotic process; however, the effect of aldosterone on the …

Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness

G Galmiche, A Pizard, A Gueret, S El Moghrabi… - …, 2014 - Am Heart Assoc
Arterial stiffness is recognized as a risk factor for many cardiovascular diseases. Aldosterone
via its binding to and activation of the mineralocorticoid receptors (MRs) is a main regulator …