Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

K Devantier, VMS Kjær, S Griffin… - British Journal of …, 2024 - Wiley Online Library
Viroporins possess important potential as antiviral targets due to their critical roles during
virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine …

Revisiting respiratory syncytial virus's interaction with host immunity, towards novel therapeutics

C Efstathiou, SH Abidi, J Harker… - Cellular and Molecular Life …, 2020 - Springer
Every year there are> 33 million cases of Respiratory Syncytial Virus (RSV)-related
respiratory infection in children under the age of five, making RSV the leading cause of …

Bacterial and viral coinfections with the human respiratory syncytial virus

GA Pacheco, NMS Gálvez, JA Soto, CA Andrade… - Microorganisms, 2021 - mdpi.com
The human respiratory syncytial virus (hRSV) is one of the leading causes of acute lower
respiratory tract infections in children under five years old. Notably, hRSV infections can give …

How RSV proteins join forces to overcome the host innate immune response

T Van Royen, I Rossey, K Sedeyn, B Schepens… - Viruses, 2022 - mdpi.com
Respiratory syncytial virus (RSV) is the leading cause of severe acute lower respiratory tract
infections in infants worldwide. Although several pattern recognition receptors (PRRs) can …

A respiratory syncytial virus vaccine based on the small hydrophobic protein ectodomain presented with a novel lipid-based formulation is highly immunogenic and …

JM Langley, LD MacDonald, GM Weir… - The Journal of …, 2018 - academic.oup.com
Background Respiratory syncytial virus infection can cause lower respiratory tract infection
in older adults comparable to influenza, but no vaccines are available. Methods This was a …

GBP5 is an interferon-induced inhibitor of respiratory syncytial virus

Z Li, X Qu, X Liu, C Huan, H Wang, Z Zhao… - Journal of …, 2020 - Am Soc Microbiol
ABSTRACT Guanylate binding protein 5 (GBP5) belongs to the GTPase subfamily, which is
mainly induced by interferon gamma (IFN-γ) and is involved in many important cellular …

A review of therapeutics in clinical development for respiratory syncytial virus and influenza in children

EG Nicholson, FM Munoz - Clinical therapeutics, 2018 - Elsevier
Purpose Respiratory syncytial virus (RSV) and influenza are important viral pathogens
worldwide. Children, in particular, bear considerable burdens of morbidity and mortality …

Immunological features of respiratory syncytial virus-caused pneumonia—implications for vaccine design

E Rey-Jurado, AM Kalergis - International journal of molecular sciences, 2017 - mdpi.com
The human respiratory syncytial virus (hRSV) is the causative agent for high rates of
hospitalizations due to viral bronchiolitis and pneumonia worldwide. Such a disease is …

Global progress in clinical research on human respiratory syncytial virus vaccines

R Peng, C Chen, Q Chen, Y Zhang, R Huang… - Frontiers in …, 2024 - frontiersin.org
Human respiratory syncytial virus (hRSV) not only affects newborns but also older adults,
contributing to a substantial worldwide burden of disease. However, only three approved …

Modulation of host immunity by human respiratory syncytial virus virulence factors: a synergic inhibition of both innate and adaptive immunity

G Canedo-Marroquín, O Acevedo-Acevedo… - Frontiers in cellular …, 2017 - frontiersin.org
The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory
tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly …