Circadian rhythm connections to oxidative stress: implications for human health
M Wilking, M Ndiaye, H Mukhtar… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Oxygen and circadian rhythmicity are essential in a myriad of physiological
processes to maintain homeostasis, from blood pressure and sleep/wake cycles, down to …
processes to maintain homeostasis, from blood pressure and sleep/wake cycles, down to …
[HTML][HTML] Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes
AY Elizabeth, DR Weaver - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology
in virtually all cells. Disruption of the genes necessary for the circadian clock to function has …
in virtually all cells. Disruption of the genes necessary for the circadian clock to function has …
Loss of circadian clock gene expression is associated with tumor progression in breast cancer
C Cadenas, L Van De Sandt, K Edlund, M Lohr… - Cell Cycle, 2014 - Taylor & Francis
Several studies suggest a link between circadian rhythm disturbances and tumorigenesis.
However, the association between circadian clock genes and prognosis in breast cancer …
However, the association between circadian clock genes and prognosis in breast cancer …
A time to remember: the role of circadian clocks in learning and memory.
The circadian system has pronounced influence on learning and memory, manifesting as
marked changes in memory acquisition and recall across the day. From a mechanistic …
marked changes in memory acquisition and recall across the day. From a mechanistic …
Experimental 'jet lag'inhibits adult neurogenesis and produces long-term cognitive deficits in female hamsters
EM Gibson, C Wang, S Tjho, N Khattar, LJ Kriegsfeld - PloS one, 2010 - journals.plos.org
Background Circadian disruptions through frequent transmeridian travel, rotating shift work,
and poor sleep hygiene are associated with an array of physical and mental health …
and poor sleep hygiene are associated with an array of physical and mental health …
Ras-mediated deregulation of the circadian clock in cancer
Circadian rhythms are essential to the temporal regulation of molecular processes in living
systems and as such to life itself. Deregulation of these rhythms leads to failures in biological …
systems and as such to life itself. Deregulation of these rhythms leads to failures in biological …
Healthy clocks, healthy body, healthy mind
AB Reddy, JS O'Neill - Trends in cell biology, 2010 - cell.com
Circadian rhythms permeate mammalian biology. They are manifested in the temporal
organisation of behavioural, physiological, cellular and neuronal processes. Whereas it has …
organisation of behavioural, physiological, cellular and neuronal processes. Whereas it has …
The times they're a-changing: effects of circadian desynchronization on physiology and disease
Circadian rhythms are endogenous and need to be continuously entrained (synchronized)
with the environment. Entrainment includes both coupling internal oscillators to external …
with the environment. Entrainment includes both coupling internal oscillators to external …
Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action
Circadian rhythms (24h cycles) are observed in virtually all aspects of mammalian function
from expression of genes to complex physiological processes. The master clock is present in …
from expression of genes to complex physiological processes. The master clock is present in …
Chronotherapy and the molecular clock: Clinical implications in oncology
PF Innominato, FA Lévi, GA Bjarnason - Advanced drug delivery reviews, 2010 - Elsevier
The circadian timing system drives daily rhythmic changes in drug metabolism and controls
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …