Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy
Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …
Development of L-asparaginase biobetters: current research status and review of the desirable quality profiles
LP Brumano, FVS da Silva, TA Costa-Silva… - … in bioengineering and …, 2019 - frontiersin.org
L-Asparaginase (ASNase) is a vital component of the first line treatment of acute
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …
Enzyme engineering: Resha** the biocatalytic functions
Enzyme engineering is a powerful tool to fine‐tune the enzymes. It is a technique by which
the stability, activity, and specificity of the enzymes can be altered. The characteristic …
the stability, activity, and specificity of the enzymes can be altered. The characteristic …
Structural and biochemical properties of L‐asparaginase
l‐Asparaginase (a hydrolase converting l‐asparagine to l‐aspartic acid) was the first
enzyme to be used in clinical practice as an anticancer agent after its approval in 1978 as a …
enzyme to be used in clinical practice as an anticancer agent after its approval in 1978 as a …
Purification and Characterization of a Novel and Robust L-Asparaginase Having Low-Glutaminase Activity from Bacillus licheniformis: In Vitro Evaluation of Anti …
L-asparaginase having low glutaminase has been a key therapeutic agent in the treatment
of acute lymphpoblastic leukemia (ALL). In the present study, an extracellular L …
of acute lymphpoblastic leukemia (ALL). In the present study, an extracellular L …
Fungal endophytes: an untapped source of biocatalysts
TS Suryanarayanan, N Thirunavukkarasu… - Fungal Diversity, 2012 - Springer
Horizontally transmitted endophytes are an ecological group of fungi that infect living plant
tissues and survive in them without causing any disease symptoms. Even as facets of the …
tissues and survive in them without causing any disease symptoms. Even as facets of the …
Microbial production, molecular modification, and practical application of L-asparaginase: A review
Y Wang, W Xu, H Wu, W Zhang, C Guang… - International Journal of …, 2021 - Elsevier
Abstract L-Asparaginase (L-ASNase, EC 3.5. 1.1), an antitumor drug for acute lymphoblastic
leukemia (ALL) therapy, is widely used in the clinical field. Similarly, L-ASNase is also a …
leukemia (ALL) therapy, is widely used in the clinical field. Similarly, L-ASNase is also a …
[HTML][HTML] Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells
The antitumor enzyme asparaginase, which targets essential amino acid L-asparagine and
catalyzes it to L-aspartic acid and ammonia, has been used for years in the treatment of …
catalyzes it to L-aspartic acid and ammonia, has been used for years in the treatment of …
Molecular analysis of L-asparaginases for clarification of the mechanism of action and optimization of pharmacological functions
MV Pokrovskaya, VS Pokrovsky, SS Aleksandrova… - Pharmaceutics, 2022 - mdpi.com
L-asparaginases (EC 3.5. 1.1) are a family of enzymes that catalyze the hydrolysis of L-
asparagine to L-aspartic acid and ammonia. These proteins with different biochemical …
asparagine to L-aspartic acid and ammonia. These proteins with different biochemical …
Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment
Cancer is the second leading cause of death globally. Chemotherapy and radiation therapy
and other medications are employed to treat various types of cancer. However, each …
and other medications are employed to treat various types of cancer. However, each …