Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …

Importance Characterizing longitudinal patterns of regional brain volume changes in a
population with normal cognition at the individual level could improve understanding of the …

As we grow older, we may grow wiser, but we can also experience memory loss and
cognitive slowing that can interfere with our daily routines. The cognitive neuroscience of …

In this review, we report on studies that have assessed the effects of exogenous and
endogenous increases in stress hormones on human cognitive performance. We first …

The human brain changes with age. However, the rate and the trajectories of change vary
among the brain regions and among individuals, and the reasons for these differences are …

There is consistent evidence that brain volume changes in early and late life. Most
longitudinal studies usually only span a few years and include a limited number of …

Normal aging is accompanied by global as well as regional structural changes. While these
age-related changes in gray matter volume have been extensively studied, less has been …

During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …

Amyloid plaques and neurofibrillary tangles (NFTs) are the pathological hallmarks of
Alzheimer disease (AD). There is controversy regarding the use of current diagnostic criteria …