Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …

The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic,
whereas the microenvironment of tissues affected by chronic inflammatory disease is pro …

Disordered metabolic states, which are characterised by hypoxia and elevated levels of
metabolites, particularly lactate, contribute to the immunosuppression in the tumour …

Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …

Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …

Lactate in tumors has long been considered “metabolic junk” derived from the glycolysis of
cancer cells and utilized only as a biomarker of malignancy, but is presently believed to be a …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …

Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator
of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate …

Cancer is a metabolic disease in which abnormally proliferating cancer cells rewire
metabolic pathways in the tumor microenvironment (TME). Molecular reprogramming in the …