Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …

Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular
condensates,,–. The functions of condensates span many length scales: they modulate …

Artificial organelles can manipulate cellular functions and introduce non-biological
processes into cells. Coacervate droplets have emerged as a close analog of …

Understanding the relationship between a polypeptide sequence and its phase separation
has important implications for analysing cellular function, treating disease and designing …

Compartmentalization is an essential feature of eukaryotic life and is achieved both via
membrane-bound organelles, such as mitochondria, and membrane-less biomolecular …

Many intrinsically disordered proteins (IDPs) may undergo liquid–liquid phase separation
(LLPS) and participate in the formation of membraneless organelles in the cell, thereby …

Understanding intracellular phase separation is crucial for deciphering transcriptional
control, cell fate transitions, and disease mechanisms. However, the key residues, which …

Intrinsically disordered proteins rich in cationic amino acid groups can undergo Liquid-
Liquid Phase Separation (LLPS) in the presence of charge-balancing anionic counterparts …

Methods for selective covalent modification of amino acids on proteins can enable a diverse
array of applications, spanning probes and modulators of protein function to proteomics …