Non-AUG translation initiation in mammals
DE Andreev, G Loughran, AD Fedorova… - Genome Biology, 2022 - Springer
Recent proteogenomic studies revealed extensive translation outside of annotated protein
coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non …
coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non …
Surviving and adapting to stress: translational control and the integrated stress response
Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …
response pathways that serve to restore proteostasis and enhance survival. A primary …
mRNA structure regulates protein expression through changes in functional half-life
Messenger RNAs (mRNAs) encode information in both their primary sequence and their
higher order structure. The independent contributions of factors like codon usage and …
higher order structure. The independent contributions of factors like codon usage and …
CRISPR/Cas13 effectors have differing extents of off-target effects that limit their utility in eukaryotic cells
CRISPR/Cas13 effectors have garnered increasing attention as easily customizable tools for
detecting and depleting RNAs of interest. Near perfect complementarity between a target …
detecting and depleting RNAs of interest. Near perfect complementarity between a target …
Selective 40S footprinting reveals cap-tethered ribosome scanning in human cells
Translation regulation occurs largely during the initiation phase. Here, we develop selective
40S footprinting to visualize initiating 40S ribosomes on endogenous mRNAs in vivo. This …
40S footprinting to visualize initiating 40S ribosomes on endogenous mRNAs in vivo. This …
Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM
AB Loveland, E Svidritskiy, D Susorov, S Lee… - Nature …, 2022 - nature.com
Toxic dipeptide-repeat (DPR) proteins are produced from expanded G4C2 repeats in the
C9ORF72 gene, the most common genetic cause of amyotrophic lateral sclerosis (ALS) and …
C9ORF72 gene, the most common genetic cause of amyotrophic lateral sclerosis (ALS) and …
iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation
Post-translational modification of ribosomal proteins enables rapid and dynamic regulation
of protein biogenesis. Site-specific ubiquitylation of 40S ribosomal proteins uS10 and eS10 …
of protein biogenesis. Site-specific ubiquitylation of 40S ribosomal proteins uS10 and eS10 …
Nuclear release of eIF1 restricts start-codon selection during mitosis
Regulated start-codon selection has the potential to reshape the proteome through the
differential production of upstream open reading frames, canonical proteins, and alternative …
differential production of upstream open reading frames, canonical proteins, and alternative …
Humans and other commonly used model organisms are resistant to cycloheximide-mediated biases in ribosome profiling experiments
Ribosome profiling measures genome-wide translation dynamics at sub-codon resolution.
Cycloheximide (CHX), a widely used translation inhibitor to arrest ribosomes in these …
Cycloheximide (CHX), a widely used translation inhibitor to arrest ribosomes in these …
Small open reading frames, how to find them and determine their function
Advances in genomics and molecular biology have revealed an abundance of small open
reading frames (sORFs) across all types of transcripts. While these sORFs are often …
reading frames (sORFs) across all types of transcripts. While these sORFs are often …