DNA replication in eukaryotic cells
SP Bell, A Dutta - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …
replication of the entire genome each time a cell divides. To achieve this coordination …
Eukaryotic DNA replication fork
PMJ Burgers, TA Kunkel - Annual review of biochemistry, 2017 - annualreviews.org
This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
Concerted loading of Mcm2–7 double hexamers around DNA during DNA replication origin licensing
The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle
replication, involves the loading of six related minichromosome maintenance proteins …
replication, involves the loading of six related minichromosome maintenance proteins …
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins
MCM2-7 proteins provide essential helicase functions in eukaryotes at chromosomal DNA
replication forks. During the G1 phase of the cell cycle, they remain loaded on DNA but are …
replication forks. During the G1 phase of the cell cycle, they remain loaded on DNA but are …
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication …
Evidence obtained from studies with yeast and Xenopusindicate that the initiation of DNA
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …
Eukaryotic chromosome DNA replication: where, when, and how?
H Masai, S Matsumoto, Z You… - Annual review of …, 2010 - annualreviews.org
DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …
Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase
SE Moyer, PW Lewis… - Proceedings of the …, 2006 - National Acad Sciences
The protein Cdc45 plays a critical but poorly understood role in the initiation and elongation
stages of eukaryotic DNA replication. To study Cdc45's function in DNA replication, we …
stages of eukaryotic DNA replication. To study Cdc45's function in DNA replication, we …
Eukaryotic MCM proteins: beyond replication initiation
SL Forsburg - Microbiology and Molecular Biology Reviews, 2004 - Am Soc Microbiol
The minichromosome maintenance (or MCM) protein family is composed of six related
proteins that are conserved in all eukaryotes. They were first identified by genetic screens in …
proteins that are conserved in all eukaryotes. They were first identified by genetic screens in …
Mechanisms for initiating cellular DNA replication
BACKGROUND Cellular life depends on the ability of organisms to accurately duplicate and
transmit genetic information between generations. In bacteria, archaea, and eukaryotes, this …
transmit genetic information between generations. In bacteria, archaea, and eukaryotes, this …
[HTML][HTML] Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase
The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism. In
some models, CMG encircles and translocates along one strand of DNA while excluding the …
some models, CMG encircles and translocates along one strand of DNA while excluding the …