Advances in the study of mRNAs have yielded major new insights into post-transcriptional
control of gene expression. Focus on the spatial regulation of mRNAs in highly polarized …

During oogenesis, several developmental processes must be traversed to ensure effective
completion of gametogenesis including, stem cell maintenance and asymmetric division …

The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where
control is passed from the maternal to the zygotic genome. Although the MZT is typically …

In sexually reproducing animals, the oocyte contributes a large supply of RNAs that are
essential to launch development upon fertilization. The mechanisms that regulate the …

Gamete formation from germline stem cells (GSCs) is essential for sexual reproduction.
However, the regulation of GSC differentiation is incompletely understood. Set2, which …

Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase
ribosome biogenesis and translation during terminal differentiation. Here, we show that the …

Ribosomal defects perturb stem cell differentiation, and this is the cause of ribosomopathies.
How ribosome levels control stem cell differentiation is not fully known. Here, we discover …

Following fertilization, the unified germ cells rapidly transition to a totipotent embryo.
Maternally deposited mRNAs encode the proteins necessary for this reprogramming as the …

Many maternal mRNAs are translationally repressed during oocyte development and spatio-
temporally activated during early embryogenesis, which is crucial for oocyte and early …

Study of the timing and location for mRNA translation across model systems has begun to
shed light on molecular events fundamental to such processes as intercellular …