Compressive stresses in cancer: characterization and implications for tumour progression and treatment

JA Linke, LL Munn, RK Jain - Nature Reviews Cancer, 2024 - nature.com
Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Probing the physical hallmarks of cancer

HT Nia, LL Munn, RK Jain - Nature Methods, 2025 - nature.com
The physical microenvironment plays a crucial role in tumor development, progression,
metastasis and treatment. Recently, we proposed four physical hallmarks of cancer, with …

Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression

Y Zhu, J Chen, C Chen, R Tang, J Xu, S Shi, X Yu - Biomarker Research, 2025 - Springer
The tumor microenvironment functions as a dynamic and intricate ecosystem, comprising a
diverse array of cellular and non-cellular components that precisely orchestrate pivotal …