Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells
Rare multipotent haematopoietic stem cells (HSCs) in adult bone marrow with extensive self-
renewal potential can efficiently replenish all myeloid and lymphoid blood cells, securing …
renewal potential can efficiently replenish all myeloid and lymphoid blood cells, securing …
HMGB2 loss upon senescence entry disrupts genomic organization and induces CTCF clustering across cell types
Processes like cellular senescence are characterized by complex events giving rise to
heterogeneous cell populations. However, the early molecular events driving this cascade …
heterogeneous cell populations. However, the early molecular events driving this cascade …
[HTML][HTML] Computational advances of tumor marker selection and sample classification in cancer proteomics
Cancer proteomics has become a powerful technique for characterizing the protein markers
driving transformation of malignancy, tracing proteome variation triggered by therapeutics …
driving transformation of malignancy, tracing proteome variation triggered by therapeutics …
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis
Mammalian chromosomes are three-dimensional entities shaped by converging and
opposing forces. Mitotic cell division induces marked chromosome condensation, but …
opposing forces. Mitotic cell division induces marked chromosome condensation, but …
mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense …
JL Anderson, TS Mulligan, MC Shen, H Wang… - PLoS …, 2017 - journals.plos.org
As model organism-based research shifts from forward to reverse genetics approaches,
largely due to the ease of genome editing technology, a low frequency of abnormal …
largely due to the ease of genome editing technology, a low frequency of abnormal …
Isochronic development of cortical synapses in primates and mice
The neotenous, or delayed, development of primate neurons, particularly human ones, is
thought to underlie primate-specific abilities like cognition. We tested whether synaptic …
thought to underlie primate-specific abilities like cognition. We tested whether synaptic …
[HTML][HTML] Primate neuronal connections are sparse in cortex as compared to mouse
Detailing how primate and mouse neurons differ is critical for creating generalized models of
how neurons process information. We reconstruct 15,748 synapses in adult Rhesus …
how neurons process information. We reconstruct 15,748 synapses in adult Rhesus …
The life cycle of radio galaxies in the LOFAR Lockman Hole field
Radio galaxies are known to go through cycles of activity, where phases of apparent
quiescence can be followed by repeated activity of the central supermassive black hole. A …
quiescence can be followed by repeated activity of the central supermassive black hole. A …
Plant virus particles with various shapes as potential adjuvants
EA Evtushenko, EM Ryabchevskaya, NA Nikitin… - Scientific reports, 2020 - nature.com
Plant viruses are biologically safe for mammals and can be successfully used as a
carrier/platform to present foreign epitopes in the course of creating novel putative vaccines …
carrier/platform to present foreign epitopes in the course of creating novel putative vaccines …
State-Dependent Inhibition of Nav1. 8 Sodium Channels by VX-150 and VX-548
ABSTRACT Nav1. 8 sodium channels (Nav1. 8) are an attractive therapeutic target for pain
because they are prominent in primary pain-sensing neurons with little expression in most …
because they are prominent in primary pain-sensing neurons with little expression in most …